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  • 产品名称：Anti-EEF2K antibody (406-725) (STJ27357)

  • 产品型号：STJ27357
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-EEF2K antibody (406-725) (STJ27357)
详情介绍：
Host: Rabbit
Applications: WB/IF
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-EEF2K (406-725) is suitable for use in Western Blot and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:2000
IF/ICC 1:50-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: EEF2K
Gene ID: 29904
Uniprot ID: EF2K_HUMAN
Immunogen Region: 406-725
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 406-725 of human EEF2K (NP_037434.1).
Immunogen Sequence: KLDHLHWPVFSDLDNMASRD HDHLDNHRESENSGDSGYPS EKRGELDDPEPREHGHSYSN RKYESDEDSLGSSGRVCVEK WNLLNSSRLHLPRASAVALE VQRLNALDLEKKIGKSILGK VHLAMVRYHEGGRFCEKGEE WDQESAVFHLEHAANLGELE AIVGLGLMYSQLPHHILADV SLKETEENKTKGFDYLLKAA EAGDRQSMILVARAFDSGQN LSPDRCQDWLEALHWYNTA
Post Translational Modifications Autophosphorylated at multiple residues, Thr-348 being the major site. Phosphorylated by AMP-activated protein kinase AMPK at Ser-398 leading to EEF2K activation and protein synthesis inhibition. Phosphorylated by TRPM7 at Ser-78 resulting in improved protein stability, higher EE2F phosphorylated and subsequently reduced rate of protein synthesis. Phosphorylation by other kinases such as CDK1 and MAPK13 at Ser-359 or RPS6KA1 and RPS6KB1 at Ser-366 instead decrease EEF2K activity and promote protein synthesis.
Function Threonine kinase that regulates protein synthesis by controlling the rate of peptide chain elongation. Upon activation by a variety of upstream kinases including AMPK or TRPM7, phosphorylates the elongation factor EEF2 at a single site, renders it unable to bind ribosomes and thus inactive. In turn, the rate of protein synthesis is reduced.
Protein Name Eukaryotic Elongation Factor 2 Kinase
Eef-2 Kinase
Eef-2k
Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase
Database Links Reactome: R-HSA-166208
Alternative Antibody Names Anti-Eukaryotic Elongation Factor 2 Kinase antibody
Anti-Eef-2 Kinase antibody
Anti-Eef-2k antibody
Anti-Calcium/Calmodulin-Dependent Eukaryotic Elongation Factor 2 Kinase antibody
Anti-EEF2K antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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