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  • 产品名称：Anti-ERAP1 antibody (642-941) (STJ111244)

  • 产品型号：STJ111244
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ERAP1 antibody (642-941) (STJ111244)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ERAP1 (642-941) is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:1000-1:2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ERAP1
Gene ID: 51752
Uniprot ID: ERAP1_HUMAN
Immunogen Region: 642-941
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 642-941 of human ERAP1 (NP_001185470.1).
Immunogen Sequence: NAFQLVSIGKLSIEKALDLS LYLKHETEIMPVFQGLNELI PMYKLMEKRDMNEVETQFKA FLIRLLRDLIDKQTWTDEGS VSERMLRSQLLLLACVHNYQ PCVQRAEGYFRKWKESNGNL SLPVDVTLAVFAVGAQSTEG WDFLYSKYQFSLSSTEKSQI EFALCRTQNKEKLQWLLDES FKGDKIKTQEFPQILTLIGR NPVGYPLAWQFLRKNWNKLV QKFELGSSSIAHMVMGTTN
Tissue Specificity Ubiquitous.
Post Translational Modifications N-glycosylated.
Function Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney.
Protein Name Endoplasmic Reticulum Aminopeptidase 1
Arts-1
Adipocyte-Derived Leucine Aminopeptidase
A-Lap
Aminopeptidase Pils
Puromycin-Insensitive Leucyl-Specific Aminopeptidase
Pils-Ap
Type 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator
Database Links Reactome: R-HSA-983170
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Ii Membrane Protein
Alternative Antibody Names Anti-Endoplasmic Reticulum Aminopeptidase 1 antibody
Anti-Arts-1 antibody
Anti-Adipocyte-Derived Leucine Aminopeptidase antibody
Anti-A-Lap antibody
Anti-Aminopeptidase Pils antibody
Anti-Puromycin-Insensitive Leucyl-Specific Aminopeptidase antibody
Anti-Pils-Ap antibody
Anti-Type 1 Tumor Necrosis Factor Receptor Shedding Aminopeptidase Regulator antibody
Anti-ERAP1 antibody
Anti-APPILS antibody
Anti-ARTS1 antibody
Anti-KIAA0525 antibody
Anti-UNQ584 antibody
Anti-PRO1154 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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