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  • 产品名称：Anti-ERCC6L antibody (STJA0007388)

  • 产品型号：STJA0007388
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-ERCC6L antibody (STJA0007388)
详情介绍：
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-DNA excision repair protein ERCC-6-like is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ERCC6L
Gene ID: 54821
Uniprot ID: ERC6L_HUMAN
Specificity: This antibody detects endogenous levels of ERCC6L at Human, Mouse
Immunogen: Synthesized peptide derived from human ERCC6L
Function DNA helicase that acts as a tension sensor that associates with catenated DNA which is stretched under tension until it is resolved during anaphase. Functions as ATP-dependent DNA translocase. Can promote Holliday junction branch migration (in vitro).
Protein Name Dna Excision Repair Protein Ercc-6-Like
Atp-Dependent Helicase Ercc6-Like
Plk1-Interacting Checkpoint Helicase
Tumor Antigen Bj-Hcc-15
Database Links Reactome: R-HSA-141444
Reactome: R-HSA-2467813
Reactome: R-HSA-2500257
Reactome: R-HSA-5663220
Reactome: R-HSA-68877
Reactome: R-HSA-9648025
Cellular Localisation Chromosome
Centromere
Kinetochore
Localizes To Kinetochores
Inner Centromeres And Thin Threads Connecting Separating Chromosomes Even During Anaphase
In Prometaphase Cells
It Mostly Concentrates In Between Kinetochores
In Metaphase
It Localizes To Numerous Thin Threads That Stretch Between Sister Kinetochores Of The Aligned Chromosomes And Are Composed Of Catenated Centromeric Dna
Evolution From Inner Centromeres To Thin Threads Takes Place In Response To Tension
Resolution Of Thin Threads Requires Topoisomerase 2-Alpha (Top2a) After Anaphase Onset
Alternative Antibody Names Anti-Dna Excision Repair Protein Ercc-6-Like antibody
Anti-Atp-Dependent Helicase Ercc6-Like antibody
Anti-Plk1-Interacting Checkpoint Helicase antibody
Anti-Tumor Antigen Bj-Hcc-15 antibody
Anti-ERCC6L antibody
Anti-PICH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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