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  • 产品名称：Mouse SPTLC1 (Serine Palmitoyltransferase, Long Chain Base Subunit 1) Sandwich ELISA Kit Ready-To-Use (STJE0018715)

  • 产品型号：STJE0018715
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Mouse SPTLC1 (Serine Palmitoyltransferase, Long Chain Base Subunit 1) Sandwich ELISA Kit Ready-To-Use (STJE0018715)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.055ng/mL
Detection Limit: 0.156-10ng/mL
Short Description: This SPTLC1 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Sptlc1
Gene ID: 268656
Uniprot ID: SPTC1_MOUSE
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in a variety of tissues. Highest expression in brain, kidney and liver. Expressed in brown and white adipose tissues.
Post Translational Modifications Phosphorylation at Tyr-164 inhibits activity and promotes cell survival.
Function Component of the serine palmitoyltransferase multisubunit enzyme (SPT) that catalyzes the initial and rate-limiting step in sphingolipid biosynthesis by condensing L-serine and activated acyl-CoA (most commonly palmitoyl-CoA) to form long-chain bases. The SPT complex is also composed of SPTLC2 or SPTLC3 and SPTSSA or SPTSSB. Within this complex, the heterodimer with SPTLC2 or SPTLC3 forms the catalytic core. The composition of the serine palmitoyltransferase (SPT) complex determines the substrate preference. The SPTLC1-SPTLC2-SPTSSA complex shows a strong preference for C16-CoA substrate, while the SPTLC1-SPTLC3-SPTSSA isozyme uses both C14-CoA and C16-CoA as substrates, with a slight preference for C14-CoA. The SPTLC1-SPTLC2-SPTSSB complex shows a strong preference for C18-CoA substrate, while the SPTLC1-SPTLC3-SPTSSB isozyme displays an ability to use a broader range of acyl-CoAs, without apparent preference. Required for adipocyte cell viability and metabolic homeostasis.
Protein Name Serine Palmitoyltransferase 1
Long Chain Base Biosynthesis Protein 1
Lcb 1
Serine-Palmitoyl-Coa Transferase 1
Spt 1
Spt1
Database Links Reactome: R-MMU-1660661
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Membrane Protein
Alternative ELISA Names Serine Palmitoyltransferase 1 ELISA kit
Long Chain Base Biosynthesis Protein 1 ELISA kit
Lcb 1 ELISA kit
Serine-Palmitoyl-Coa Transferase 1 ELISA kit
Spt 1 ELISA kit
Spt1 ELISA kit
Sptlc1 ELISA kit
Lcb1 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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