产品详情
查看大图

  • 产品名称：Mouse XRCC6 (X-Ray Repair Cross Complementing 6) Sandwich ELISA Kit (STJE0013132)

  • 产品型号：STJE0013132
  • 产品厂商：ST john's laboratory
  • 产品文档：
你添加了1件商品 查看购物车
简单介绍：
Mouse XRCC6 (X-Ray Repair Cross Complementing 6) Sandwich ELISA Kit (STJE0013132)
详情介绍：
Applications: ELISA
Reactivity: Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.107ng/mL
Detection Limit: 0.312-20ng/mL
Short Description: This XRCC6 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse cell culture supernatant, serum and plasma (EDTA, citrate, heparin).
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 4.5 hrs
Gene Symbol: Xrcc6
Gene ID: 14375
Uniprot ID: XRCC6_MOUSE
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity
Post Translational Modifications Phosphorylation by PRKDC may enhance helicase activity. Phosphorylation of Ser-49 does not affect DNA repair. ADP-ribosylated by PARP3.
Function Single-stranded DNA-dependent ATP-dependent helicase that plays a key role in DNA non-homologous end joining (NHEJ) by recruiting DNA-PK to DNA. Required for double-strand break repair and V(D)J recombination. Also has a role in chromosome translocation. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. During NHEJ, the XRCC5-XRRC6 dimer performs the recognition step: it recognizes and binds to the broken ends of the DNA and protects them from further resection. Binding to DNA may be mediated by XRCC6. The XRCC5-XRRC6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic subunit PRKDC to DNA by 100-fold. The XRCC5-XRRC6 dimer is probably involved in stabilizing broken DNA ends and bringing them together. The assembly of the DNA-PK complex to DNA ends is required for the NHEJ ligation step. Probably also acts as a 5'-deoxyribose-5-phosphate lyase (5'-dRP lyase), by catalyzing the beta-elimination of the 5' deoxyribose-5-phosphate at an abasic site near double-strand breaks. 5'-dRP lyase activity allows to 'clean' the termini of abasic sites, a class of nucleotide damage commonly associated with strand breaks, before such broken ends can be joined. The XRCC5-XRRC6 dimer together with APEX1 acts as a negative regulator of transcription. In association with NAA15, the XRCC5-XRRC6 dimer binds to the osteocalcin promoter and activates osteocalcin expression. Plays a role in the regulation of DNA virus-mediated innate immune response by assembling into the HDP-RNP complex, a complex that serves as a platform for IRF3 phosphorylation and subsequent innate immune response activation through the cGAS-STING pathway.
Protein Name X-Ray Repair Cross-Complementing Protein 6
5'-Deoxyribose-5-Phosphate Lyase Ku70
5'-Drp/Ap Lyase Ku70
Atp-Dependent Dna Helicase 2 Subunit 1
Atp-Dependent Dna Helicase Ii 70 Kda Subunit
Ctc Box-Binding Factor 75 Kda Subunit
Ctc75
Ctcbf
Dna Repair Protein Xrcc6
Ku Autoantigen Protein P70 Homolog
Ku70
Database Links Reactome: R-MMU-5693571
Reactome: -MMU-6798695
Cellular Localisation Nucleus
Chromosome
Alternative ELISA Names X-Ray Repair Cross-Complementing Protein 6 ELISA kit
5'-Deoxyribose-5-Phosphate Lyase Ku70 ELISA kit
5'-Drp/Ap Lyase Ku70 ELISA kit
Atp-Dependent Dna Helicase 2 Subunit 1 ELISA kit
Atp-Dependent Dna Helicase Ii 70 Kda Subunit ELISA kit
Ctc Box-Binding Factor 75 Kda Subunit ELISA kit
Ctc75 ELISA kit
Ctcbf ELISA kit
Dna Repair Protein Xrcc6 ELISA kit
Ku Autoantigen Protein P70 Homolog ELISA kit
Ku70 ELISA kit
Xrcc6 ELISA kit
G22p1 ELISA kit
Ku70 ELISA kit
output

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
姓名：
电话：
您的需求：
 

沪公网安备 31011002002624号