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  • 产品名称：Anti-FH antibody (45-510) (STJ27655)

  • 产品型号：STJ27655
  • 产品厂商：ST john's laboratory
  • 产品文档：
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简单介绍：
Anti-FH antibody (45-510) (STJ27655)
详情介绍：
Host: Rabbit
Applications: WB/IHC/IF
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-FH (45-510) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:100-1:500
IHC-P 1:50-1:200
IF/ICC 1:50-1:100
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: FH
Gene ID: 2271
Uniprot ID: FUMH_HUMAN
Immunogen Region: 45-510
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 45-510 of human FH (NP_000134.2).
Immunogen Sequence: ASQNSFRIEYDTFGELKVPN DKYYGAQTVRSTMNFKIGGV TERMPTPVIKAFGILKRAAA EVNQDYGLDPKIANAIMKAA DEVAEGKLNDHFPLVVWQTG SGTQTNMNVNEVISNRAIEM LGGELGSKIPVHPNDHVNKS QSSNDTFPTAMHIAAAIEVH EVLLPGLQKLHDALDAKSKE FAQIIKIGRTHTQDAVPLTL GQEFSGYVQQVKYAMTRIKA AMPRIYELAAGGTAVGTGL
Tissue Specificity Expressed in red blood cells.underexpressed in red blood cells (cytoplasm) of patients with hereditary non-spherocytic hemolytic anemia of unknown etiology.
Post Translational Modifications Isoform Cytoplasmic: Phosphorylation at Thr-236 by PRKDC in response to DNA damage promotes translocation to the nucleus and recruitment to DNA double-strand breaks (DSBs).
Function Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in other species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). Isoform Mitochondrial: Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. Isoform Cytoplasmic: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism.fumarate being a by-product of the urea cycle and amino-acid catabolism. Also plays a role in DNA repair by promoting non-homologous end-joining (NHEJ). In response to DNA damage and phosphorylation by PRKDC, translocates to the nucleus and accumulates at DNA double-strand breaks (DSBs): acts by catalyzing formation of fumarate, an inhibitor of KDM2B histone demethylase activity, resulting in enhanced dimethylation of histone H3 'Lys-36' (H3K36me2).
Protein Name Fumarate Hydratase - Mitochondrial
Fumarase
Hsfh
Database Links Reactome: R-HSA-71403
Cellular Localisation Isoform Mitochondrial: Mitochondrion
Isoform Cytoplasmic: Cytoplasm
Cytosol
Nucleus
Chromosome
Translocates To The Nucleus In Response To Dna Damage: Localizes To Dna Double-Strand Breaks (Dsbs) Following Phosphorylation By Prkdc
Alternative Antibody Names Anti-Fumarate Hydratase - Mitochondrial antibody
Anti-Fumarase antibody
Anti-Hsfh antibody
Anti-FH antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
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