产品详情
简单介绍：
Fibrinogen (citrullinated) mouse monoclonal antibody, clone 20B2, Purified
详情介绍：
| Product Data | |
| Clone Name | 20B2 |
|---|---|
| Application | ELISA |
| Recommended Dilution | ELISA. |
| Reactivity | Human, Mouse |
| Antibody Host | Mouse |
| Isotype | IgG1 |
| Clonality | Monoclonal |
| Immunogen | Deiminated Murine Fibrinogen peptide. |
| Specificity |
Specificity has been tested in ELISA (Figure 1). |
| Buffer |
10mM Ammonium Bicarbonate buffer State: Purified State: Lyophilized purified Ig fraction |
| Reconstitution Method | Restore in 200µl. |
| Concentration | lot specific |
| Purification | Protein A Chromatography |
| Conjugation | Unconjugated |
| Storage |
Store the antibody undiluted at 2-8°C . Add 0.05% Sodium Azide for longer storage. |
| Stability | Shelf life: one year from despatch. |
| Shipping | Ambient |
| Background | Fibrinogen is a protein produced by the liver which helps stop bleeding by helping blood clots to form. Fibrinogen gets deiminated (conversion from arginin to citrullin) by Peptidyl Arginine Deïminase (PAD) in inflamed joints in patients that develop rheumatoid arthritis.Citrulline, while being an amino acid, is not built into proteins during protein synthesis, as it is not coded for by DNA, yet several proteins are known to contain citrulline. These citrulline residues are generated by a family of enzymes called peptidylarginine deiminases (PADs), which convert arginine into citrulline in a process called citrullination or deimination. Proteins that normally contain citrulline residues include myelin basic protein (MBP), filaggrin, and several histone proteins, while other proteins, like fibrin and vimentin can get citrullinated during cell death and tissue inflammation. Patients with rheumatoid arthritis often (at least 80% of them) develop an immune response against proteins containing citrulline. Although the origin of this immune response is not known, detection of antibodies reactive with citrulline containing proteins or peptides is now becoming an important help in the diagnosis of rheumatoid arthritis. |
| Synonyms | FGA, FGB, FGG |
| Note |
Recommended Solvent: 100 mM PBS or Tris-HCl, pH 7.0–8.0 |
相关信息
- 细胞培养玄学-MRC-5细胞 2025-01-07
- Ocean NanoTech定制的详细步骤 2021-10-31
- click chemistry tools数据结果比... 2021-10-31
- LaysanBio代理商相关文献资料2020 2021-10-31
- Abbiotec代理的产品得到重复验证2020 2021-10-31
- zyagen Laboratories代理的产品得到... 2021-06-20
- Toxin Technologies代理商相关文献资... 2021-03-14
- 热烈祝贺玉博生物正式代理biocolor公司试剂产品... 2021-03-14
- 热烈祝贺玉博生物正式代理cytognos公司试剂产品... 2021-03-14
- Gelest代理的产品得到重复验证2020 2021-03-14
